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Title:

Rapid and Robust Continuous Purification of High-Titer Hepatitis B Virus for In Vitro and In Vivo Applications.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wettengel, Jochen M; Linden, Bianca; Esser, Knud; Laue, Michael; Burwitz, Benjamin J; Protzer, Ulrike
Abstract:
Available treatments for hepatitis B can control the virus but are rarely curative. This led to a global initiative to design new curative therapies for the 257 million patients affected. Discovery and development of these new therapies is contingent upon functional in vitro and in vivo hepatitis B virus (HBV) infection models. However, low titer and impurity of conventional HBV stocks reduce significance of in vitro infections and moreover limit challenge doses in current in vivo models. Theref...     »
Journal title abbreviation:
Viruses
Year:
2021
Journal volume:
13
Journal issue:
8
Fulltext / DOI:
doi:10.3390/v13081503
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34452368
Print-ISSN:
1999-4915
TUM Institution:
Institut für Virologie
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