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Titel:

HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site.

Dokumenttyp:
Journal Article; Review
Autor(en):
Zhang, Dake; Zhang, Ke; Protzer, Urlike; Zeng, Changqing
Abstract:
Hepatitis B virus (HBV), one of the well-known DNA oncogenic viruses, is the leading cause of hepatocellular carcinoma (HCC). In infected hepatocytes, HBV DNA can be integrated into the host genome through an insertional mutagenesis process inducing tumorigenesis. Dissection of the genomic features surrounding integration sites will deepen our understanding of mechanisms underlying integration. Moreover, the quantity and biological activity of integration sites may reflect the DNA damage within...     »
Zeitschriftentitel:
J Clin Transl Hepatol
Jahr:
2021
Band / Volume:
9
Heft / Issue:
3
Seitenangaben Beitrag:
399-408
Volltext / DOI:
doi:10.14218/JCTH.2021.00062
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34221926
Print-ISSN:
2225-0719
TUM Einrichtung:
Institut für Virologie
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