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Titel:

SETD1A/COMPASS a locus-specific co-regulator of the Glucocorticoid Receptor in murine macrophages

Dokumenttyp:
Konferenzbeitrag
Art des Konferenzbeitrags:
Poster
Autor(en):
Dr. Franziska Greulich
Seitenangaben Beitrag:
1
Abstract:
Glucocorticoids (GCs) are potent anti-inflammatory drugs, widely prescribed. They repress pro-inflammatory genes and induce anti-inflammatory and metabolic genes by binding to the glucocorticoid receptor (GR). Here we try to decipher the molecular mechanism of gene repression and activation in the same cell type by profiling nuclear interaction partners of the GR. We found that GR interacts with the COMPASS/SETD1A complex, which is recruited to activating GR binding sites (GBS). A Setd1a hyper...     »
Dewey-Dezimalklassifikation:
070 Publizistische Medien, Journalismus, Verlagswesen
Kongress- / Buchtitel:
CSH Meeting "Epigenetics&Chromatin"
Ausrichter der Konferenz:
CSH
Datum der Konferenz:
15.09.-18.09.2020
Jahr:
2020
Sprache:
en
Erscheinungsform:
WWW
TUM Einrichtung:
Professur Metabolic Programming
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