User: Guest  Login
Title:

SETD1A/COMPASS a locus-specific co-regulator of the Glucocorticoid Receptor in murine macrophages

Document type:
Konferenzbeitrag
Contribution type:
Poster
Author(s):
Dr. Franziska Greulich
Pages contribution:
1
Abstract:
Glucocorticoids (GCs) are potent anti-inflammatory drugs, widely prescribed. They repress pro-inflammatory genes and induce anti-inflammatory and metabolic genes by binding to the glucocorticoid receptor (GR). Here we try to decipher the molecular mechanism of gene repression and activation in the same cell type by profiling nuclear interaction partners of the GR. We found that GR interacts with the COMPASS/SETD1A complex, which is recruited to activating GR binding sites (GBS). A Setd1a hyper...     »
Dewey Decimal Classification:
070 Publizistische Medien, Journalismus, Verlagswesen
Book / Congress title:
CSH Meeting "Epigenetics&Chromatin"
Organization:
CSH
Date of congress:
15.09.-18.09.2020
Year:
2020
Language:
en
Publication format:
WWW
TUM Institution:
Professur Metabolic Programming
 BibTeX