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Title:

Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms.

Document type:
Review; Journal Article; Review
Author(s):
Grabuschnig, Stefan; Bronkhorst, Abel Jacobus; Holdenrieder, Stefan; Rosales Rodriguez, Ingund; Schliep, Klaus Peter; Schwendenwein, Daniel; Ungerer, Vida; Sensen, Christoph Wilhelm
Abstract:
Through various pathways of cell death, degradation, and regulated extrusion, partial or complete genomes of various origins (e.g., host cells, fetal cells, and infiltrating viruses and microbes) are continuously shed into human body fluids in the form of segmented cell-free DNA (cfDNA) molecules. While the genetic complexity of total cfDNA is vast, the development of progressively efficient extraction, high-throughput sequencing, characterization via bioinformatics procedures, and detection hav...     »
Journal title abbreviation:
Int J Mol Sci
Year:
2020
Journal volume:
21
Journal issue:
21
Fulltext / DOI:
doi:10.3390/ijms21218062
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33137955
Print-ISSN:
1422-0067
TUM Institution:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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