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Title:

Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative.

Document type:
Journal Article
Author(s):
Guimaraes, Julio Brandao; Nevitt, Michael C; McCulloch, Charles E; Schwaiger, Benedikt J; Gersing, Alexandra S; Facchetti, Luca; Bucknor, Matthew D; Chanchek, Nattagan; Liu, Felix; Joseph, Gabby B; Link, Thomas M
Abstract:
OBJECTIVES: To investigate the association of weight change over 48 months with progression of meniscal intrasubstance degeneration (MID). METHODS: We studied 487 subjects with MID at baseline and after 48 months using 3-T MRI with the same protocol (FSE sequences with and without fat suppression). These participants lost weight (≥3%, n = 141), had moderate weight gain (3-10%, n = 77), substantial weight gain (>10%, n = 15) or maintained stable weight (n = 254). Progression of MID to a meniscal tear was assessed using the WORMS grading system and compared among weight change groups using logistic regression. ANOVA and chi-square tests were used to study the differences in subjects' characteristics. RESULTS: Progression of MID increased from weight loss to substantial weight gain (p < 0.001) and was significantly more likely with both moderate weight gain (odds ratio [OR], 4.9; 95% confidence interval [CI] 2.4-8.9) and substantial weight gain (OR, 9.5; 95% CI 3.2-28.5) compared to stable weight. Results were similar in both menisci for moderate weight gain (medial: OR, 6.8; 95% CI 3.5-11.3; lateral: OR, 2.6; 95% CI 1.1-6.6) and substantial weight gain (medial: OR, 21.0; 95% CI 5.1-80.7; lateral: OR, 9.7; 95% CI 0.95-100.2). CONCLUSION: Weight gain is associated with an increased likelihood that meniscal intrasubstance degeneration will progress with the risk increasing with greater weight gain. KEY POINTS: • Subjects who gained weight were more likely to develop meniscal tears. • Greater amount of weight gain was associated with an increasing likelihood of progression. • Prevention of weight gain has health benefits for the meniscus.
Journal title abbreviation:
Eur Radiol
Year:
2018
Journal volume:
28
Journal issue:
3
Pages contribution:
953-962
Fulltext / DOI:
doi:10.1007/s00330-017-5054-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28986637
Print-ISSN:
0938-7994
TUM Institution:
Institut für Diagnostische und Interventionelle Radiologie
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