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Title:

Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis.

Document type:
Journal Article
Author(s):
Demir, Ihsan Ekin; Heinrich, Tobias; Carty, Dominique G; Saricaoglu, Ömer Cemil; Klauss, Sarah; Teller, Steffen; Kehl, Timo; Mota Reyes, Carmen; Tieftrunk, Elke; Lazarou, Maria; Bahceci, Dorukhan H; Gökcek, Betül; Ucurum, Bahar E; Maak, Matthias; Diakopoulos, Kalliope N; Lesina, Marina; Schemann, Michael; Erkan, Mert; Krüger, Achim; Algül, Hana; Friess, Helmut; Ceyhan, Güralp O
Abstract:
BACKGROUND: Pain due to pancreatic cancer/PCa or chronic pancreatitis/CP, is notoriously resistant to the strongest pain medications. Here, we aimed at deciphering the specific molecular mediators of pain at surgical-stage pancreatic disease and to discover novel translational targets. METHODS: We performed a systematic, quantitative analysis of the neurotransmitter/neuroenzmye profile within intrapancreatic nerves of CP and PCa patients. Ex vivo neuronal cultures treated with human pancreatic e...     »
Journal title abbreviation:
EBioMedicine
Year:
2019
Journal volume:
46
Pages contribution:
431-443
Fulltext / DOI:
doi:10.1016/j.ebiom.2019.07.055
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31401195
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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