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Title:

Important role of Nfkb2 in the KrasG12D-driven carcinogenesis in the pancreas.

Document type:
Journal Article
Author(s):
Hassan, Zonera; Schneeweis, Christian; Wirth, Matthias; Müller, Sebastian; Geismann, Claudia; Neuß, Thorsten; Steiger, Katja; Krämer, Oliver H; Schmid, Roland M; Rad, Roland; Arlt, Alexander; Reichert, Maximilian; Saur, Dieter; Schneider, Günter
Abstract:
BACKGROUND: Oncogenic Kras initiates and drives carcinogenesis in the pancreas by complex signaling networks, including activation of the NFκB pathway. Although recent evidence has shown that oncogenic gains in Nfκb2 collaborate with Kras in the carcinogenesis, no data at the level of genetics for the contribution of Nfκb2 is available so far. METHODS: We used Nfkb2 knock-out mice to decipher the role of the gene in Kras-driven carcinogenesis in vivo. RESULTS: We show that the Nfkb2 gene is need...     »
Journal title abbreviation:
Pancreatology
Year:
2021
Journal volume:
21
Journal issue:
5
Pages contribution:
912-919
Fulltext / DOI:
doi:10.1016/j.pan.2021.03.012
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33824054
Print-ISSN:
1424-3903
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Innere Medizin II, Gastroenterologie; Lehrstuhl für Translationale Tumorforschung (DKTK) (Prof. Saur); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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