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Title:

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lankes, Katharina; Hassan, Zonera; Doffo, María Josefina; Schneeweis, Christian; Lier, Svenja; Öllinger, Rupert; Rad, Roland; Krämer, Oliver H; Keller, Ulrich; Saur, Dieter; Reichert, Maximilian; Schneider, Günter; Wirth, Matthias
Abstract:
The myelocytomatosis oncogene (MYC) is an important driver in a subtype of pancreatic ductal adenocarcinoma (PDAC). However, MYC remains a challenging therapeutic target; therefore, identifying druggable synthetic lethal interactions in MYC-active PDAC may lead to novel precise therapies. First, to identify networks with hyperactive MYC, we profiled transcriptomes of established human cell lines, murine primary PDAC cell lines, and accessed publicly available repositories to analyze transcripto...     »
Journal title abbreviation:
Mol Oncol
Year:
2020
Journal volume:
14
Journal issue:
12
Pages contribution:
3048-3064
Fulltext / DOI:
doi:10.1002/1878-0261.12835
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33099868
Print-ISSN:
1574-7891
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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