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Title:

mRNA 3'UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bergant, Valter; Schnepf, Daniel; de Andrade Krätzig, Niklas; Hubel, Philipp; Urban, Christian; Engleitner, Thomas; Dijkman, Ronald; Ryffel, Bernhard; Steiger, Katja; Knolle, Percy A; Kochs, Georg; Rad, Roland; Staeheli, Peter; Pichlmair, Andreas
Abstract:
Changes of mRNA 3'UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain enigmatic. By combining transcriptomics, proteomics and recombinant viruses we show that all tested strains of IAV, including A/PR/8/34(H1N1) (PR8) and A/Cal/07/2009 (H1N1) (Cal09), cause APA. We mapped the effect to the highly conserved glycine residue at position 184 (G184) of the viral non-structural protein 1 (NS1). Unbiased mass spectrome...     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-40469-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37582777
Print-ISSN:
2041-1723
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für Experimentelle Onkologie und Therapieforschung; Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad); Roman Herzog Comprehensive Cancer Center
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