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Titel:

Differential effects of Belatacept on virus-specific memory versus de novo allo-specific T cell responses of kidney transplant recipients and healthy donors.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kühne, Jenny Franziska; Neudörfl, Christine; Beushausen, Kerstin; Keil, Jana; Malysheva, Svitlana; Wandrer, Franziska; Haller, Hermann; Messerle, Martin; Blume, Cornelia; Neuenhahn, Michael; Schlott, Fabian; Hammerschmidt, Wolfgang; Zeidler, Reinhard; Falk, Christine S
Abstract:
Belatacept, Nulojix®, inhibits the interaction of CD28 on naïve T cells with B7.1/B7.2 (CD80/86) on antigen presenting cells, leading to T cell hyporesponsiveness and anergy and is approved as immunosuppressive drug in kidney transplantation. Due to its specificity for B7.1/2 molecules, side effects are reduced compared to other immunosuppressive drugs like calcineurin- and mTOR-inhibitors. Kidney transplant recipients under Belatacept-based immunosuppression presented with superior renal functi...     »
Zeitschriftentitel:
Transpl Immunol
Jahr:
2020
Band / Volume:
61
Volltext / DOI:
doi:10.1016/j.trim.2020.101291
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32330566
Print-ISSN:
0966-3274
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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