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Titel:

The Aurora-Kinase A Phe31-Ile polymorphism as possible predictor of response to treatment in head and neck squamous cell carcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Baumann, Alexander; Buchberger, Anna Maria S; Piontek, Guido; Schüttler, Dominik; Rudelius, Martina; Reiter, Rudolf; Gebel, Lena; Piendl, Gerhard; Brockhoff, Gero; Pickhard, Anja
Abstract:
Recently the Aurora-Kinases (Aurk) moved into the focus as novel disease related biomarkers and therapeutic targets. Elevated Aurora-Kinase expression has been found in a number of malignancies, amongst them HNSCC. For esophageal cancer, the AurkA Phe31-Ile polymorphism has previously been associated with tumor progression. Here we evaluated the treatment efficiency of HNSCC cell radiation as a function of Aurora-Kinases in HNSCC cell lines. Moreover, we investigated a potential sensitization to...     »
Zeitschriftentitel:
Oncotarget
Jahr:
2018
Band / Volume:
9
Heft / Issue:
16
Seitenangaben Beitrag:
12769-12780
Volltext / DOI:
doi:10.18632/oncotarget.24355
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29560108
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik
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