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- Title:
Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction.
- Document type:
- Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
- Author(s):
- Novotny, Julia; Oberdieck, Paul; Titova, Anna; Pelisek, Jaroslav; Chandraratne, Sue; Nicol, Philipp; Hapfelmeier, Alexander; Joner, Michael; Maegdefessel, Lars; Poppert, Holger; Pircher, Joachim; Massberg, Steffen; Friedrich, Benjamin; Zimmer, Claus; Schulz, Christian; Boeckh-Behrens, Tobias
- Abstract:
- OBJECTIVE: To investigate whether immune cell composition and content of neutrophil extracellular traps (NETs) in relation to clinical outcome are different between acute ischemic stroke (AIS) and acute myocardial infarction (AMI), we performed histologic analysis and correlated results with clinical and procedural parameters. METHODS: We retrieved thrombi from patients with AIS (n = 71) and AMI (n = 72) during endovascular arterial recanalization and analyzed their immune cell composition and NET content by immunohistology. We then associated thrombus composition with procedural parameters and outcome in AIS and with cardiac function in patients with AMI. Furthermore, we compared AIS thrombi with AMI thrombi and differentiated Trial of Org 10172 in Acute Stroke Treatment classifications to address potential differences in thrombus pathogenesis. RESULTS: Amounts of leukocytes (p = 0.133) and neutrophils (p = 0.56) were similar between AIS and AMI thrombi. Monocytes (p = 0.0052), eosinophils (p < 0.0001), B cells (p < 0.0001), and T cells (p < 0.0001) were more abundant in stroke compared with AMI thrombi. NETs were present in 100% of patients with AIS and 20.8% of patients with AMI. Their abundance in thrombi was associated with poor outcome scores in patients with AIS and with reduced ejection fraction in patients with AMI. CONCLUSION: In our detailed histologic analysis of arterial thrombi, thrombus composition and especially abundance of leukocyte subsets differed between patients with AIS and AMI. The presence and amount of NETs were associated with patients' outcome after AIS and AMI, supporting a critical impact of NETs on thrombus stability in both conditions.
- Journal title abbreviation:
- Neurology
- Year:
- 2020
- Journal volume:
- 94
- Journal issue:
- 22
- Pages contribution:
- e2346-e2360
- Fulltext / DOI:
- doi:10.1212/WNL.0000000000009532
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/32434865
- Print-ISSN:
- 0028-3878
- TUM Institution:
- Fachgebiet Gefäßchirurgie (Prof. Eckstein); Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Medizinische Statistik und Epidemiologie; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Neurologische Klinik und Poliklinik
BibTeX
Occurrences:
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)Professur für Neuroradiologie (Prof. Zimmer)2020
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineLehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen HerzzentrumKlinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2020
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für Neurologie (Prof. Hemmer)2020
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für KI und Informatik in der Medizin (Prof. Rückert)2020
- mediaTUM GesamtbestandHochschulbibliographie2020FakultätenMedizinInstitut für Medizinische Statistik und Epidemiologie