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Titel:

Metabolic control by S6 kinases depends on dietary lipids.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Article
Autor(en):
Castañeda, TR; Abplanalp, W; Um, SH; Pfluger, PT; Schrott, B; Brown, K; Grant, E; Carnevalli, L; Benoit, SC; Morgan, DA; Gilham, D; Hui, DY; Rahmouni, K; Thomas, G; Kozma, SC; Clegg, DJ; Tschöp, MH
Abstract:
Targeted deletion of S6 kinase (S6K) 1 in mice leads to higher energy expenditure and improved glucose metabolism. However, the molecular mechanisms controlling these effects remain to be fully elucidated. Here, we analyze the potential role of dietary lipids in regulating the mTORC1/S6K system. Analysis of S6K phosphorylation in vivo and in vitro showed that dietary lipids activate S6K, and this effect is not dependent upon amino acids. Comparison of male mice lacking S6K1 and 2 (S6K-dko) with...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2012
Band / Volume:
7
Heft / Issue:
3
Seitenangaben Beitrag:
e32631
Volltext / DOI:
doi:10.1371/journal.pone.0032631
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22412899
Print-ISSN:
1932-6203
TUM Einrichtung:
Kliniken und Institute
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