Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus that has an increasing clinical prevalence. Patients with EoE exhibit other atopic diseases and IgE-mediated sensitisations against food and aeroallergens, often without obvious clinical relevance. The pathophysiology of EoE is a non-IgE-mediated Th2-dominated cellular eosinophilic hypersensitivity against food allergens. The diagnosis is based upon clinical symptoms of an esophageal dysfunction as well as the histology-proven eosinophilia in the esophagus, which requires regular endoscopies with biopsies. Effective therapeutic options are topical steroids, proton pump inhibitors, and elimination diets. Up to now, empirical elimination diets have shown superiority over individual allergy test-driven elimination diets.     «

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus that has an increasing clinical prevalence. Patients with EoE exhibit other atopic diseases and IgE-mediated sensitisations against food and aeroallergens, often without obvious clinical relevance. The pathophysiology of EoE is a non-IgE-mediated Th2-dominated cellular eosinophilic hypersensitivity against food allergens. The diagnosis is based upon clinical symptoms of an esophageal dysfunction as well as the hist...     »