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Title:

Model-Based Inference and Classification of Immunologic Control Mechanisms from TKI Cessation and Dose Reduction in Patients with CML.

Document type:
Article; Journal Article; Comment
Author(s):
Hähnel, Tom; Baldow, Christoph; Guilhot, Joëlle; Guilhot, François; Saussele, Susanne; Mustjoki, Satu; Jilg, Stefanie; Jost, Philipp J; Dulucq, Stephanie; Mahon, François-Xavier; Roeder, Ingo; Fassoni, Artur C; Glauche, Ingmar
Abstract:
Recent clinical findings in patients with chronic myeloid leukemia (CML) suggest that the risk of molecular recurrence after stopping tyrosine kinase inhibitor (TKI) treatment substantially depends on an individual's leukemia-specific immune response. However, it is still not possible to prospectively identify patients that will remain in treatment-free remission (TFR). Here, we used an ordinary differential equation model for CML, which explicitly includes an antileukemic immunologic effect, an...     »
Journal title abbreviation:
Cancer Res
Year:
2020
Journal volume:
80
Journal issue:
11
Pages contribution:
2394-2406
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-19-2175
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32041835
Print-ISSN:
0008-5472
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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