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Titel:

Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class 1 Expression on Ewing's Sarcoma, Enhancing T Cell Cytotoxicity.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Biele, Emilie; Schober, Sebastian J; Prexler, Carolin; Thiede, Melanie; Heyking, Kristina von; Gassmann, Hendrik; Eck, Jennifer; Xue, Busheng; Burdach, Stefan; Thiel, Uwe
Abstract:
Ewing's sarcoma (EwS) is a pediatric solid tumor entity with low somatic mutational burden and a low rate of tumor-infiltrating T cells, indicating a low extent of immunogenicity. In EwS, immunogenicity may furthermore be significantly diminished by a predominantly M2 macrophage driven pro-tumorigenic tumor microenvironment. In the past, we demonstrated that CHM1319-specific TCR-transgenic T cells are able to control EwS growth in a preclinical mouse model as well as in a patient with metastatic...     »
Zeitschriftentitel:
Cells
Jahr:
2021
Band / Volume:
10
Heft / Issue:
11
Volltext / DOI:
doi:10.3390/cells10113070
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34831294
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Kinder- und Jugendmedizin
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