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Titel:

Native glycan fragments detected by MALDI mass spectrometry imaging are independent prognostic factors in pancreatic ductal adenocarcinoma.

Dokumenttyp:
Article; Journal Article
Autor(en):
Sun, Na; Trajkovic-Arsic, Marija; Li, Fengxia; Wu, Yin; Münch, Corinna; Kunzke, Thomas; Feuchtinger, Annette; Steiger, Katja; Schlitter, Anna Melissa; Weichert, Wilko; Esposito, Irene; Siveke, Jens T; Walch, Axel
Abstract:
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies to date. The impressively developed stroma that surrounds and modulates the behavior of cancer cells is one of the main factors regulating the PDAC growth, metastasis and therapy resistance. Here, we postulate that stromal and cancer cell compartments differentiate in protein/lipid glycosylation patterns and analyze differences in glycan fragments in those compartments with clinicopathologic correlates....     »
Zeitschriftentitel:
EJNMMI Res
Jahr:
2021
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s13550-021-00862-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34851463
Print-ISSN:
2191-219X
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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