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Title:

In silico study on radiobiological efficacy of Ac-225 and Lu-177 for PSMA-guided radiotherapy.

Document type:
Journal Article
Author(s):
Birindelli, Gabriele; Drobnjakovic, Milos; Morath, Volker; Steiger, Katja; D'Alessandria, Calogero; Gourni, Eleni; Afshar-Oromieh, Ali; Weber, Wolfgang; Rominger, Axel; Eiber, Matthias; Shi, Kuangyu
Abstract:
The good efficacy of radioligand therapy (RLT) targeting prostate specific-membrane antigen (PSMA) for the treatment of metastatic castration-resistant prostate cancer (mCRPC) has been recently demonstrated in several clinical studies. However, the treatment effect of 177Lu-PSMA-ligands is still suboptimal for a significant fraction of patients. In contrast to external beam radiotherapy, the radiation dose distribution itself is strongly influenced by the heterogeneous tumour microenvironment. A...     »
Journal title abbreviation:
Annu Int Conf IEEE Eng Med Biol Soc
Year:
2021
Journal volume:
2021
Pages contribution:
4497-4500
Fulltext / DOI:
doi:10.1109/EMBC46164.2021.9630297
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34892217
Print-ISSN:
2375-7477
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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