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Titel:

Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.

Dokumenttyp:
Journal Article
Autor(en):
Gong, Weiwei; Zhu, Caixia; Liu, Yueyang; Muckenhuber, Alexander; Bronger, Holger; Scorilas, Andreas; Kiechle, Marion; Dorn, Julia; Magdolen, Viktor; Dreyer, Tobias
Abstract:
Triple-negative breast cancer (TNBC) patients have the worst outcome among all breast cancer subtypes. In oral squamous carcinoma cells, miR-378 was reported to target the mRNA of kallikrein-related peptidase 4 (KLK4), resulting in inhibition of cell proliferation, migration and invasion, induction of apoptosis, and reduction of tumor growth in vivo. Similarly, a miR-378/KLK4 axis has been proposed in prostate cancer. Here, we analyzed the correlation between miR-378 and KLK4 mRNA expression and...     »
Zeitschriftentitel:
Am J Transl Res
Jahr:
2021
Band / Volume:
13
Heft / Issue:
3
Seitenangaben Beitrag:
1594-1606
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33841682
Print-ISSN:
1943-8141
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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