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Title:

Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity.

Document type:
Journal Article
Author(s):
Baldini, Francesca; Fabbri, Rita; Eberhagen, Carola; Voci, Adriana; Portincasa, Piero; Zischka, Hans; Vergani, Laura
Abstract:
AIMS: Adipocyte hypertrophy is the main cause of obesity. A deeper understanding of the molecular mechanisms regulating adipocyte dysfunction may help to plan strategies to treat/prevent obesity and its metabolic complications. Here, we investigated in vitro the molecular alterations associated with early adipocyte hypertrophy, focusing on mitochondrial dysfunction. MAIN METHODS: As model of adipocyte hypertrophy, we employed 3T3-L1 preadipocytes firstly differentiated into mature adipocytes, th...     »
Journal title abbreviation:
Life Sci
Year:
2021
Journal volume:
265
Fulltext / DOI:
doi:10.1016/j.lfs.2020.118812
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33278396
Print-ISSN:
0024-3205
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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