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Titel:

CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion.

Dokumenttyp:
Journal Article
Autor(en):
Russo, Gianluca L; Sonsalla, Giovanna; Natarajan, Poornemaa; Breunig, Christopher T; Bulli, Giorgia; Merl-Pham, Juliane; Schmitt, Sabine; Giehrl-Schwab, Jessica; Giesert, Florian; Jastroch, Martin; Zischka, Hans; Wurst, Wolfgang; Stricker, Stefan H; Hauck, Stefanie M; Masserdotti, Giacomo; Götz, Magdalena
Abstract:
Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy. Neurons are particularly dependent on mitochondrial function, but how well mitochondria adapt to the new fate is unknown. Here, we determined the comprehensive mitochondrial proteome of cortical astrocytes and neurons, identifying about 150 significantly enriched mitochondrial proteins for each cell type, including transporters, metabolic enzymes, and cell-type-specific antioxidants. Monitoring their transitio...     »
Zeitschriftentitel:
Cell Stem Cell
Jahr:
2021
Band / Volume:
28
Heft / Issue:
3
Seitenangaben Beitrag:
524-534.e7
Volltext / DOI:
doi:10.1016/j.stem.2020.10.015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33202244
Print-ISSN:
1934-5909
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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