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Titel:

Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation.

Dokumenttyp:
Journal Article
Autor(en):
Kabiri, Yaschar; Fuhrmann, Anna; Becker, Anna; Jedermann, Luisa; Eberhagen, Carola; König, Ann-Christine; Silva, Tiago Barros; Borges, Fernanda; Hauck, Stefanie M; Michalke, Bernhard; Knolle, Percy; Zischka, Hans
Abstract:
Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS). Upregulation of ALR was observed in multiple forms of cancer, among them hepatocellular carcinoma (HCC). To shed light into ALR function in HCC, we used MitoBloCK-6 to pharmacologically inhibit ALR, resulting in profound mitochondrial impairment and cancer cell proliferation deficits. The...     »
Zeitschriftentitel:
Front Cell Dev Biol
Jahr:
2021
Band / Volume:
9
Volltext / DOI:
doi:10.3389/fcell.2021.725474
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34616733
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Institut für Toxikologie und Umwelthygiene; Roman Herzog Comprehensive Cancer Center
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