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Titel:

Differential Prognostic Value of Galectin-3 According to Carbohydrate Antigen 125 Levels in Transcatheter Aortic Valve Implantation.

Dokumenttyp:
Journal Article
Autor(en):
Rheude, Tobias; Pellegrini, Costanza; Núñez, Julio; Joner, Michael; Trenkwalder, Teresa; Mayr, N Patrick; Holdenrieder, Stefan; Bodí, Vicent; Koenig, Wolfgang; Kasel, Albert M; Schunkert, Heribert; Kastrati, Adnan; Hengstenberg, Christian; Husser, Oliver
Abstract:
INTRODUCTION AND OBJECTIVES: Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have been associated with adverse outcomes after transcatheter aortic valve implantation (TAVI). Experimental data have suggested a potential molecular interaction. Therefore, we assessed the association of Gal-3 and CA125 with prognosis after TAVI. METHODS: A total of 439 patients were enrolled. The primary endpoint was a composite of all-cause mortality or readmission for worsening heart failure after TAVI. RESULTS: The primary endpoint occurred in 16.4%. Gal-3 was dichotomized at ≥ 8.71 ng/mL into elevated and not elevated. Gal-3 was elevated in 31.9% and was associated with a higher risk of the primary endpoint (25% vs 12.4%, HR, 2.26; P<.001). After multivariable adjustment, the association of elevated Gal-3 with the primary endpoint was borderline significant (HR, 1.59; P=.068). CA125 was dichotomized at ≥ 18.4 U/mL, accordingly. CA125 was elevated in 51.9% and was also associated with a higher risk of the primary endpoint (25.4% vs 6.6%, HR, 4.20; P<.001). After multivariable adjustment, elevated CA125 (HR, 2.83; P=.001) remained independently associated with the primary endpoint. A differential prognostic effect of Gal-3 was found across CA125 status (P for interaction=.048). Elevated Gal-3 was associated with a higher risk of the primary endpoint when CA125 was elevated (38.8% vs 18.2%, HR, 2.02; P=.015) but lacked significance when CA125 was not elevated (6.6% vs 6.7%, HR, 1.16; P=.981). CONCLUSIONS: In patients undergoing TAVI, Gal-3 predicted adverse clinical outcomes only when CA125 was elevated.
Zeitschriftentitel:
Rev Esp Cardiol (Engl Ed)
Jahr:
2019
Band / Volume:
72
Heft / Issue:
11
Seitenangaben Beitrag:
907-915
Volltext / DOI:
doi:10.1016/j.rec.2018.09.006
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30482731
TUM Einrichtung:
Fachgebiet Kardioanästhesie (Prof. Tassani-Prell); Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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