User: Guest  Login
Title:

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gupta, Shashi Kumar; Garg, Ankita; Avramopoulos, Petros; Engelhardt, Stefan; Streckfuss-Bömeke, Katrin; Batkai, Sandor; Thum, Thomas
Abstract:
Improved therapy of cancer has significantly increased the lifespan of patients. However, cancer survivors face an increased risk of cardiovascular complications due to adverse effects of cancer therapies. The chemotherapy drug doxorubicin is well known to induce myofibril damage and cardiac atrophy. Our aim was to test potential counteracting effects of the pro-hypertrophic miR-212/132 family in doxorubicin-induced cardiotoxicity. In vitro, overexpression of the pro-hypertrophic miR-212/132 clu...     »
Journal title abbreviation:
Mol Ther
Year:
2019
Journal volume:
27
Journal issue:
1
Pages contribution:
17-28
Fulltext / DOI:
doi:10.1016/j.ymthe.2018.11.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30527757
Print-ISSN:
1525-0016
TUM Institution:
Institut für Pharmakologie und Toxikologie
 BibTeX