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Titel:

NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kračun, Damir; Klop, Mathieu; Knirsch, Anna; Petry, Andreas; Kanchev, Ivan; Chalupsky, Karel; Wolf, Cordula M; Görlach, Agnes
Abstract:
Cardiovascular side effects are frequent problems accompanying systemic glucocorticoid therapy, although the underlying mechanisms are not fully resolved. Reactive oxygen species (ROS) have been shown to promote various cardiovascular diseases although the link between glucocorticoid and ROS signaling has been controversial. As the family of NADPH oxidases has been identified as important source of ROS in the cardiovascular system we investigated the role of NADPH oxidases in response to the syn...     »
Zeitschriftentitel:
Redox Biol
Jahr:
2020
Band / Volume:
34
Volltext / DOI:
doi:10.1016/j.redox.2020.101536
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32413743
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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