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Titel:

The alternative cap-binding complex is required for antiviral defense in vivo.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gebhardt, Anna; Bergant, Valter; Schnepf, Daniel; Moser, Markus; Meiler, Arno; Togbe, Dieudonnée; Mackowiak, Claire; Reinert, Line S; Paludan, Søren R; Ryffel, Bernhard; Stukalov, Alexey; Staeheli, Peter; Pichlmair, Andreas
Abstract:
Cellular response to environmental challenges requires immediate and precise regulation of transcriptional programs. During viral infections, this includes the expression of antiviral genes that are essential to combat the pathogen. Transcribed mRNAs are bound and escorted to the cytoplasm by the cap-binding complex (CBC). We recently identified a protein complex consisting of NCBP1 and NCBP3 that, under physiological conditions, has redundant function to the canonical CBC, consisting of NCBP1 a...     »
Zeitschriftentitel:
PLoS Pathog
Jahr:
2019
Band / Volume:
15
Heft / Issue:
12
Volltext / DOI:
doi:10.1371/journal.ppat.1008155
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31856218
Print-ISSN:
1553-7366
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); Institut für Virologie
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