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Title:

Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ziegler, Karin A; Ahles, Andrea; Wille, Timo; Kerler, Julia; Ramanujam, Deepak; Engelhardt, Stefan
Abstract:
Aims: Cardiac inflammation has been suggested to be regulated by the sympathetic nervous system (SNS). However, due to the lack of methodology to surgically eliminate the myocardial SNS in mice, neuronal control of cardiac inflammation remains ill-defined. Here, we report a procedure for local cardiac sympathetic denervation in mice and tested its effect in a mouse model of heart failure post-myocardial infarction. Methods and results: Upon preparation of the carotid bifurcation, the right and t...     »
Journal title abbreviation:
Cardiovasc Res
Year:
2018
Journal volume:
114
Journal issue:
2
Pages contribution:
291-299
Fulltext / DOI:
doi:10.1093/cvr/cvx227
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29186414
Print-ISSN:
0008-6363
TUM Institution:
Institut für Pharmakologie und Toxikologie
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