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Titel:

Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.

Dokumenttyp:
Journal Article
Autor(en):
Dedic, N; Pöhlmann, M L; Richter, J S; Mehta, D; Czamara, D; Metzger, M W; Dine, J; Bedenk, B T; Hartmann, J; Wagner, K V; Jurik, A; Almli, L M; Lori, A; Moosmang, S; Hofmann, F; Wotjak, C T; Rammes, G; Eder, M; Chen, A; Ressler, K J; Wurst, W; Schmidt, M V; Binder, E B; Deussing, J M
Abstract:
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the ?1C subunit of the voltage-gated L-type calcium channel Ca1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. However, genetic variants of complex diseases often only confer a marginal increase in disease risk, which is additionally influenced by the environment. Here we show that embryonic deletion of Cacna1c in forebrain gluta...     »
Zeitschriftentitel:
Mol Psychiatry
Jahr:
2018
Band / Volume:
23
Heft / Issue:
3
Seitenangaben Beitrag:
533-543
Sprache:
eng
Volltext / DOI:
doi:10.1038/mp.2017.133
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28696432
Print-ISSN:
1359-4184
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie; Klinik für Anästhesiologie (DHM)
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