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Title:

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.

Document type:
Journal Article
Author(s):
Vetrivel, Sharmilee; Tiso, Natascia; Kügler, Andrea; Irmler, Martin; Horsch, Marion; Beckers, Johannes; Hladik, Daniela; Giesert, Florian; Gailus-Durner, Valerie; Fuchs, Helmut; Sabrautzki, Sibylle; Adler, Thure; Treise, Irina; Busch, Dirk H; Aguilar-Pimentel, Antonio; Ollert, Markus; Götz, Alexander; Amarie, Oana V; Stoeger, Tobias; Schulz, Holger; Becker, Lore; Klopstock, Thomas; Schrewe, Anja; Spielmann, Nadine; Bekeredjian, Raffi; Garrett, Lillian; Hölter, Sabine M; Zimprich, Annemarie; Wurs...     »
Abstract:
During an ENU (N-ethyl-N-nitrosourea) mutagenesis screen, we observed a dominant small-eye mutant mouse with viable homozygotes. A corresponding mutant line was established and referred to as Aey69 (abnormality of the eye #69). Comprehensive phenotyping of the homozygous Aey69 mutants in the German Mouse Clinic revealed only a subset of statistically significant alterations between wild types and homozygous mutants. The mutation causes microphthalmia without a lens but with retinal hyperprolifer...     »
Journal title abbreviation:
Exp Eye Res
Year:
2019
Journal volume:
188
Fulltext / DOI:
doi:10.1016/j.exer.2019.03.024
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30991053
Print-ISSN:
0014-4835
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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