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Title:

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke.

Document type:
Journal Article
Author(s):
Casas, Ana I; Kleikers, Pamela Wm; Geuss, Eva; Langhauser, Friederike; Adler, Thure; Busch, Dirk H; Gailus-Durner, Valerie; de Angelis, Martin Hrabe; Egea, Javier; Lopez, Manuela G; Kleinschnitz, Christoph; Schmidt, Harald Hhw
Abstract:
Ischemic stroke is a predominant cause of disability worldwide, with thrombolytic or mechanical removal of the occlusion being the only therapeutic option. Reperfusion bears the risk of an acute deleterious calcium-dependent breakdown of the blood-brain barrier. Its mechanism, however, is unknown. Here, we identified type 5 NADPH oxidase (NOX5), a calcium-activated, ROS-forming enzyme, as the missing link. Using a humanized knockin (KI) mouse model and in vitro organotypic cultures, we found tha...     »
Journal title abbreviation:
J Clin Invest
Year:
2019
Journal volume:
129
Journal issue:
4
Pages contribution:
1772-1778
Fulltext / DOI:
doi:10.1172/JCI124283
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30882367
Print-ISSN:
0021-9738
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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