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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Mejías-Luque, Raquel; Lozano-Pope, Ivonne; Wanisch, Andreas; Heikenwälder, Matthias; Gerhard, Markus; Obonyo, Marygorret
Title:
Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection.
Abstract:
Helicobacter pylori infection induces a number of pro-inflammatory signaling pathways contributing to gastric inflammation and carcinogenesis. Among those, NF-κB signaling plays a pivotal role during infection and malignant transformation of the gastric epithelium. However, deficiency of the adaptor molecule myeloid differentiation primary response 88 (MyD88), which signals through NF-κB, led to an accelerated development of gastric pathology upon H. felis infection, but the mechanisms leading t...     »
Journal title abbreviation:
Sci Rep
Year:
2019
Journal volume:
9
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-019-43417-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31065023
Print-ISSN:
2045-2322
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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