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Titel:

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke.

Dokumenttyp:
Journal Article
Autor(en):
Casas, Ana I; Kleikers, Pamela Wm; Geuss, Eva; Langhauser, Friederike; Adler, Thure; Busch, Dirk H; Gailus-Durner, Valerie; de Angelis, Martin Hrabe; Egea, Javier; Lopez, Manuela G; Kleinschnitz, Christoph; Schmidt, Harald Hhw
Abstract:
Ischemic stroke is a predominant cause of disability worldwide, with thrombolytic or mechanical removal of the occlusion being the only therapeutic option. Reperfusion bears the risk of an acute deleterious calcium-dependent breakdown of the blood-brain barrier. Its mechanism, however, is unknown. Here, we identified type 5 NADPH oxidase (NOX5), a calcium-activated, ROS-forming enzyme, as the missing link. Using a humanized knockin (KI) mouse model and in vitro organotypic cultures, we found tha...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2019
Band / Volume:
129
Heft / Issue:
4
Seitenangaben Beitrag:
1772-1778
Volltext / DOI:
doi:10.1172/JCI124283
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30882367
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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