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Titel:

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.

Dokumenttyp:
Journal Article
Autor(en):
Zwick, Markus; Ulas, Thomas; Cho, Yi-Li; Ried, Christine; Grosse, Leonie; Simon, Charlotte; Bernhard, Caroline; Busch, Dirk H; Schultze, Joachim L; Buchholz, Veit R; Stutte, Susanne; Brocker, Thomas
Abstract:
Apoptotic cell death of Dendritic cells (DCs) is critical for immune homeostasis. Although intrinsic mechanisms controlling DC death have not been fully characterized up to now, experimentally enforced inhibition of DC-death causes various autoimmune diseases in model systems. We have generated mice deficient for Protein Phosphatase with EF-Hands 2 (Ppef2), which is selectively expressed in CD8+ DCs, but not in other related DC subtypes such as tissue CD103+ DCs. Ppef2 is down-regulated rapidly...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2019
Band / Volume:
10
Volltext / DOI:
doi:10.3389/fimmu.2019.00222
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30809231
Print-ISSN:
1664-3224
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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