Benutzer: Gast  Login
Titel:

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Autor(en):
Lowe, Margaret M; Boothby, Ian; Clancy, Sean; Ahn, Richard S; Liao, Wilson; Nguyen, David N; Schumann, Kathrin; Marson, Alexander; Mahuron, Kelly M; Kingsbury, Gillian A; Liu, Zheng; Munoz Sandoval, Priscila; Rodriguez, Robert Sanchez; Pauli, Mariela L; Taravati, Keyon; Arron, Sarah T; Neuhaus, Isaac M; Harris, Hobart W; Kim, Esther A; Shin, Uk Sok; Krummel, Matthew F; Daud, Adil; Scharschmidt, Tiffany C; Rosenblum, Michael D
Abstract:
Distinct subsets of Tregs reside in nonlymphoid tissues where they mediate unique functions. To interrogate the biology of tissue Tregs in human health and disease, we phenotypically and functionally compared healthy skin Tregs with those in peripheral blood, inflamed psoriatic skin, and metastatic melanoma. The mitochondrial enzyme, arginase 2 (ARG2), was preferentially expressed in Tregs in healthy skin, increased in Tregs in metastatic melanoma, and reduced in Tregs from psoriatic skin. ARG2...     »
Zeitschriftentitel:
JCI Insight
Jahr:
2019
Band / Volume:
4
Heft / Issue:
24
Volltext / DOI:
doi:10.1172/jci.insight.129756
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31852848
Print-ISSN:
2379-3708
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX