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Titel:

Mutated Rnf43 Aggravates Helicobacter Pylori-Induced Gastric Pathology.

Dokumenttyp:
Journal Article
Autor(en):
Neumeyer, Victoria; Vieth, Michael; Gerhard, Markus; Mejías-Luque, Raquel
Abstract:
The E3 ubiquitin ligase ring finger protein 43 (RNF43) is frequently mutated in gastric tumors and loss of RNF43 expression was suggested to be one of the key events during the transition from adenoma to gastric carcinoma. Functional studies on RNF43 have shown that it acts as a tumor suppressor by negatively regulating Wnt signaling. Interestingly, we observed that RNF43H292R/H295R mice bearing two point mutations in the ring domain displayed thickening of the mucosa at early age but did not de...     »
Zeitschriftentitel:
Cancers
Jahr:
2019
Band / Volume:
11
Heft / Issue:
3
Volltext / DOI:
doi:10.3390/cancers11030372
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30884828
Print-ISSN:
2072-6694
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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