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Title:

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.

Document type:
Journal Article
Author(s):
Mueller, Sebastian; Engleitner, Thomas; Maresch, Roman; Zukowska, Magdalena; Lange, Sebastian; Kaltenbacher, Thorsten; Konukiewitz, Björn; Öllinger, Rupert; Zwiebel, Maximilian; Strong, Alex; Yen, Hsi-Yu; Banerjee, Ruby; Louzada, Sandra; Fu, Beiyuan; Seidler, Barbara; Götzfried, Juliana; Schuck, Kathleen; Hassan, Zonera; Arbeiter, Andreas; Schönhuber, Nina; Klein, Sabine; Veltkamp, Christian; Friedrich, Mathias; Rad, Lena; Barenboim, Maxim; Ziegenhain, Christoph; Hess, Julia; Dovey, Oliver M; Es...     »
Abstract:
The poor correlation of mutational landscapes with phenotypes limits our understanding of the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we show that oncogenic dosage-variation has a critical role in PDAC biology and phenotypic diversification. We find an increase in gene dosage of mutant KRAS in human PDAC precursors, which drives both early tumorigenesis and metastasis and thus rationalizes early PDAC dissemination. To overcome the limitations posed to gene do...     »
Journal title abbreviation:
Nature
Year:
2018
Journal volume:
554
Journal issue:
7690
Pages contribution:
62-68
Language:
eng
Fulltext / DOI:
doi:10.1038/nature25459
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29364867
Print-ISSN:
0028-0836
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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