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Title:

MTOR inhibitor-based combination therapies for pancreatic cancer.

Document type:
Journal Article
Author(s):
Hassan, Zonera; Schneeweis, Christian; Wirth, Matthias; Veltkamp, Christian; Dantes, Zahra; Feuerecker, Benedikt; Ceyhan, Güralp O; Knauer, Shirley K; Weichert, Wilko; Schmid, Roland M; Stauber, Roland; Arlt, Alexander; Krämer, Oliver H; Rad, Roland; Reichert, Maximilian; Saur, Dieter; Schneider, Günter
Abstract:
Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification.We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and...     »
Journal title abbreviation:
Br J Cancer
Year:
2018
Journal volume:
118
Journal issue:
3
Pages contribution:
366-377
Language:
eng
Fulltext / DOI:
doi:10.1038/bjc.2017.421
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29384525
Print-ISSN:
0007-0920
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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