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Titel:

Inactive Gingipains from Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Glowczyk, Izabela; Wong, Alicia; Potempa, Barbara; Babyak, Olena; Lech, Maciej; Lamont, Richard J; Potempa, Jan; Koziel, Joanna
Abstract:
Gingipain cysteine proteases are considered key virulence factors of . They significantly influence antibacterial and homeostatic functions of macrophages, neutrophils, the complement system, and cytokine networks. Recent data indicate the role of in T cell differentiation; however, the involvement of gingipains in this process remains elusive. Therefore, the aim of this study was to investigate the contribution of danger signals triggered by the gingipains on the generation of Th17 cells, whi...     »
Zeitschriftentitel:
Front Cell Infect Microbiol
Jahr:
2017
Band / Volume:
7
Seitenangaben Beitrag:
140
Volltext / DOI:
doi:10.3389/fcimb.2017.00140
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28497028
Print-ISSN:
2235-2988
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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