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Titel:

Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes.

Dokumenttyp:
Article; Journal Article
Autor(en):
Popovic, David; Ruef, Anne; Dwyer, Dominic B; Antonucci, Linda A; Eder, Julia; Sanfelici, Rachele; Kambeitz-Ilankovic, Lana; Oztuerk, Omer Faruk; Dong, Mark S; Paul, Riya; Paolini, Marco; Hedderich, Dennis; Haidl, Theresa; Kambeitz, Joseph; Ruhrmann, Stephan; Chisholm, Katharine; Schultze-Lutter, Frauke; Falkai, Peter; Pergola, Giulio; Blasi, Giuseppe; Bertolino, Alessandro; Lencer, Rebekka; Dannlowski, Udo; Upthegrove, Rachel; Salokangas, Raimo K R; Pantelis, Christos; Meisenzahl, Eva; Wood, St...     »
Abstract:
BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and heterogeneous effects on brain morphology might demand advanced mathematical modeling. Therefore, we present an unsupervised machine learning approach to characterize the clinical and neuroanatomical complexity of CT in a larger, transdiagnostic context. METHODS: We used a multicenter European cohort of 1076 female and male individuals (discovery: n = 649; replication:...     »
Zeitschriftentitel:
Biol Psychiatry
Jahr:
2020
Band / Volume:
88
Heft / Issue:
11
Seitenangaben Beitrag:
829-842
Volltext / DOI:
doi:10.1016/j.biopsych.2020.05.020
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32782139
Print-ISSN:
0006-3223
TUM Einrichtung:
1477; 1695; 595; Fachgebiet Neuroradiologie (Prof. Zimmer)
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