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Title:

Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Pröbstel, Anne-Katrin; Zhou, Xiaoyuan; Baumann, Ryan; Wischnewski, Sven; Kutza, Michael; Rojas, Olga L; Sellrie, Katrin; Bischof, Antje; Kim, Kicheol; Ramesh, Akshaya; Dandekar, Ravi; Greenfield, Ariele L; Schubert, Ryan D; Bisanz, Jordan E; Vistnes, Stephanie; Khaleghi, Khashayar; Landefeld, James; Kirkish, Gina; Liesche-Starnecker, Friederike; Ramaglia, Valeria; Singh, Sneha; Tran, Edwina B; Barba, Patrick; Zorn, Kelsey; Oechtering, Johanna; Forsberg, Karin; Shiow, Lawrence R; Henry, Roland G;...     »
Abstract:
Changes in gut microbiota composition and a diverse role of B cells have recently been implicated in multiple sclerosis (MS), a central nervous system (CNS) autoimmune disease. Immunoglobulin A (IgA) is a key regulator at the mucosal interface. However, whether gut microbiota shape IgA responses and what role IgA+ cells have in neuroinflammation are unknown. Here, we identify IgA-bound taxa in MS and show that IgA-producing cells specific for MS-associated taxa traffic to the inflamed CNS, resul...     »
Journal title abbreviation:
Sci Immunol
Year:
2020
Journal volume:
5
Journal issue:
53
Fulltext / DOI:
doi:10.1126/sciimmunol.abc7191
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33219152
Print-ISSN:
2470-9468
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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