Oxidative and Nitrosative Stress in Oral Squamous Cell Carcinoma.

Frohwitter, Gesche; Zimmermann, Ornella Lisa; Kreutzer, Kilian; Doll, Christian; Rendenbach, Carsten M; Dommisch, Henrik; Wolff, Klaus-Dietrich; Kesting, Marco R; Heiland, Max; Koerdt, Steffen

doi:10.1159/000508705

2020

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Title:: Oxidative and Nitrosative Stress in Oral Squamous Cell Carcinoma.
Document type:: Article; Journal Article
Author(s):: Frohwitter, Gesche; Zimmermann, Ornella Lisa; Kreutzer, Kilian; Doll, Christian; Rendenbach, Carsten M; Dommisch, Henrik; Wolff, Klaus-Dietrich; Kesting, Marco R; Heiland, Max; Koerdt, Steffen
Abstract:: INTRODUCTION: The incidence of oral squamous cell carcinoma (OSCC) shows a constant increase, while the long-term outcome remains poor over the last decades. Radical oxygen and nitrogen species (RONS) - initially released by carcinogens, such as alcohol and tobacco, and later maintained by the tumor microenvironment - appear to be strongly associated to chronic inflammation, tumor induction, progression, and metastatic spread. The aim of this study was to evaluate the role of oxidative and nitrosative stress in primary OSCC compared to healthy tissue specimens and to identify their impact on tumor carcinogenesis. MATERIALS AND METHODS: In this basic research study, tissue samples of 30 patients with primary OSCC were evaluated for the expression of pAKT, pERK, 3-NT, NOS1, NOS3, MAPK1, and IP-8 by immunohistochemistry and RT-PCR and compared to those of a healthy control group (n = 30). RESULTS: The results showed a significantly increased expression of pAKT (p < 0.001), pERK (p = 0.01), 3-NT (p = 0.039), NOS1 (p = 0.025), NOS3 (p = 0.046), and MAPK1 (p = 0.032) in OSCC tissue samples compared to healthy controls. CONCLUSION: The results of this study prove the tested stable degradation products to be suitable for the detection of RONS in OSCC. Moreover, the significantly increased expression underlines the role of RONS in carcinogenesis of OSCC, suggests specific mechanisms of detection, and anticipates supplementary research.
Journal title abbreviation:: Cells Tissues Organs
Year:: 2020
Journal volume:: 209
Journal issue:: 2-3
Pages contribution:: 120-127
Fulltext / DOI:: doi:10.1159/000508705
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/32756061
Print-ISSN:: 1422-6405
TUM Institution:: Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie (Prof. Wolff)2020