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Document type:
Journal Article 
Author(s):
Biederstädt, Alexander; Hassan, Zonera; Schneeweis, Christian; Schick, Markus; Schneider, Lara; Muckenhuber, Alexander; Hong, Yingfen; Siegers, Gerrit; Nilsson, Lisa; Wirth, Matthias; Dantes, Zahra; Steiger, Katja; Schunck, Kathrin; Langston, Steve; Lenhof, H-P; Coluccio, Andrea; Orben, Felix; Slawska, Jolanta; Scherger, Anna; Saur, Dieter; Müller, Stefan; Rad, Roland; Weichert, Wilko; Nilsson, Jonas; Reichert, Maximilian; Schneider, Günter; Keller, Ulrich 
Title:
SUMO pathway inhibition targets an aggressive pancreatic cancer subtype. 
Abstract:
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) still carries a dismal prognosis with an overall 5-year survival rate of 9%. Conventional combination chemotherapies are a clear advance in the treatment of PDAC; however, subtypes of the disease exist, which exhibit extensive resistance to such therapies. Genomic MYC amplifications represent a distinct subset of PDAC with an aggressive tumour biology. It is clear that hyperactivation of MYC generates dependencies that can be exploited therapeu...    »
 
Journal title abbreviation:
Gut 
Year:
2020 
Journal volume:
69 
Journal issue:
Pages contribution:
1472-1482 
Print-ISSN:
0017-5749 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)