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Title:

Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.

Document type:
Journal Article
Author(s):
Meßner, Martina; Schmitt, Sabine; Ardelt, Maximilian A; Fröhlich, Thomas; Müller, Martin; Pein, Helmut; Huber-Cantonati, Petra; Ortler, Carina; Koenig, Lars M; Zobel, Lena; Koeberle, Andreas; Arnold, Georg J; Rothenfußer, Simon; Kiemer, Alexandra K; Gerbes, Alexander L; Zischka, Hans; Vollmar, Angelika M; Pachmayr, Johanna
Abstract:
Sorafenib represents the current standard of care for patients with advanced-stage hepatocellular carcinoma (HCC). However, acquired drug resistance occurs frequently during therapy and is accompanied by rapid tumor regrowth after sorafenib therapy termination. To identify the mechanism of this therapy-limiting growth resumption, we established robust sorafenib resistance HCC cell models that exhibited mitochondrial dysfunction and chemotherapeutic crossresistance. We found a rapid relapse of tu...     »
Journal title abbreviation:
FASEB J
Year:
2020
Journal volume:
34
Journal issue:
9
Pages contribution:
11860-11882
Fulltext / DOI:
doi:10.1096/fj.202001128R
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32652772
Print-ISSN:
0892-6638
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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