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Title:

Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response.

Document type:
Journal Article
Author(s):
Simoes, Ines C M; Karkucinska-Wieckowska, Agnieszka; Janikiewicz, Justyna; Szymanska, Sylwia; Pronicki, Maciej; Dobrzyn, Pawel; Dabrowski, Michal; Dobrzyn, Agnieszka; Oliveira, Paulo J; Zischka, Hans; Potes, Yaiza; Wieckowski, Mariusz R
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is characterized by the development of steatosis, which can ultimately compromise liver function. Mitochondria are key players in obesity-induced metabolic disorders; however, the distinct role of hypercaloric diet constituents in hepatic cellular oxidative stress and metabolism is unknown. Male mice were fed either a high-fat (HF) diet, a high-sucrose (HS) diet or a combined HF plus HS (HFHS) diet for 16 weeks. This study shows that hypercaloric diets c...     »
Journal title abbreviation:
Antioxidants (Basel)
Year:
2020
Journal volume:
9
Journal issue:
10
Fulltext / DOI:
doi:10.3390/antiox9100995
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33076261
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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