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Titel:

IL-18 but Not IL-1 Signaling Is Pivotal for the Initiation of Liver Injury in Murine Non-Alcoholic Fatty Liver Disease.

Dokumenttyp:
Journal Article
Autor(en):
Hohenester, Simon; Kanitz, Veronika; Schiergens, Tobias; Einer, Claudia; Nagel, Jutta; Wimmer, Ralf; Reiter, Florian P; Gerbes, Alexander L; De Toni, Enrico N; Bauer, Christian; Holdt, Lesca; Mayr, Doris; Rust, Christian; Schnurr, Max; Zischka, Hans; Geier, Andreas; Denk, Gerald
Abstract:
Non-alcoholic fatty liver disease (NAFLD) is rising in prevalence, and a better pathophysiologic understanding of the transition to its inflammatory phenotype (NASH) is key to the development of effective therapies. To evaluate the contribution of the NLRP3 inflammasome and its downstream effectors IL-1 and IL-18 in this process, we applied the true-to-life "American lifestyle-induced obesity syndrome" (ALiOS) diet mouse model. Development of obesity, fatty liver and liver damage was investigate...     »
Zeitschriftentitel:
Int J Mol Sci
Jahr:
2020
Band / Volume:
21
Heft / Issue:
22
Volltext / DOI:
doi:10.3390/ijms21228602
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33202693
Print-ISSN:
1422-0067
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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