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Title:

Modulation of Endoplasmic Reticulum Stress Influences Ischemia-Reperfusion Injury After Hemorrhagic Shock.

Document type:
Journal Article
Author(s):
Obert, David Peter; Wolpert, Alexander Karl; Korff, Sebastian
Abstract:
BACKGROUND: Impaired function of the endoplasmic reticulum (ER) results in ER stress, an accumulation of proteins in the ER lumen. ER stress is a major contributor to inflammatory diseases and is part of the pathomechanism of ischemia-reperfusion injury (IRI). Since severe traumatic injury is often accompanied by remote organ damage and immune cell dysfunction, we investigated the influence of ER stress modulation on the systemic inflammatory response and liver damage after hemorrhagic shock and...     »
Journal title abbreviation:
Shock
Year:
2019
Journal volume:
52
Journal issue:
5
Pages contribution:
e76-e84
Fulltext / DOI:
doi:10.1097/SHK.0000000000001298
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30499877
Print-ISSN:
1073-2322
TUM Institution:
Klinik für Anästhesiologie (DHM)
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