User: Guest  Login
Less Searchfields
Simple search
Title:

Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates.

Document type:
Journal Article; Review
Author(s):
Knerr, Patrick J; Mowery, Stephanie A; Finan, Brian; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D
Abstract:
The continued global growth in the prevalence of obesity coupled with the limited number of efficacious and safe treatment options elevates the importance of innovative pharmaceutical approaches. Combinatorial strategies that harness the metabolic benefits of multiple hormonal mechanisms have emerged at the preclinical and more recently clinical stages of drug development. A priority has been anti-obesity unimolecular peptides that function as balanced, high potency poly-agonists at two or all t...     »
Journal title abbreviation:
Peptides
Year:
2020
Journal volume:
125
Fulltext / DOI:
doi:10.1016/j.peptides.2019.170225
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31786282
Print-ISSN:
0196-9781
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
 BibTeX