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Titel:

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Tardif, Jean-Claude; Kouz, Simon; Waters, David D; Bertrand, Olivier F; Diaz, Rafael; Maggioni, Aldo P; Pinto, Fausto J; Ibrahim, Reda; Gamra, Habib; Kiwan, Ghassan S; Berry, Colin; López-Sendón, José; Ostadal, Petr; Koenig, Wolfgang; Angoulvant, Denis; Grégoire, Jean C; Lavoie, Marc-André; Dubé, Marie-Pierre; Rhainds, David; Provencher, Mylène; Blondeau, Lucie; Orfanos, Andreas; L'Allier, Philippe L; Guertin, Marie-Claude; Roubille, François
Abstract:
BACKGROUND: Experimental and clinical evidence supports the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis. METHODS: We performed a randomized, double-blind trial involving patients recruited within 30 days after a myocardial infarction. The patients were randomly assigned to receive either low-dose colchicine (0.5 mg once daily) or placebo. The pr...     »
Zeitschriftentitel:
N Engl J Med
Jahr:
2019
Band / Volume:
381
Heft / Issue:
26
Seitenangaben Beitrag:
2497-2505
Volltext / DOI:
doi:10.1056/NEJMoa1912388
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31733140
Print-ISSN:
0028-4793
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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