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Titel:

Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Peters, R; Wolf, MJ; van den Broek, M; Nuvolone, M; Dannenmann, S; Stieger, B; Rapold, R; Konrad, D; Rubin, A; Bertino, JR; Aguzzi, A; Heikenwalder, M; Knuth, AK
Abstract:
Haematopoiesis is sustained by haematopoietic (HSC) and mesenchymal stem cells (MSC). HSC are the precursors for blood cells, whereas marrow, stroma, bone, cartilage, muscle and connective tissues derive from MSC. The generation of MSC from umbilical cord blood (UCB) is possible, but with low and unpredictable success. Here we describe a novel, robust stroma-free dual cell culture system for long-term expansion of primitive UCB-derived MSC.UCB-derived mononuclear cells (MNC) or selected CD34(+)...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2010
Band / Volume:
5
Heft / Issue:
12
Seitenangaben Beitrag:
e15689
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0015689
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21209896
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Virologie
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